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Measuring Electrostatic Charges In Pharmaceutical Powders
The presence of electrostatic charges in powder induces adhesion and cohesion leading to intermittent or blocked flow and consequently non-uniformity of dosage.
Measuring the ability of a powder to charge during a flow was a challenge...
Electrostatic Charges In Powders
The presence of electrostatic charges in powder induces adhesion and cohesion leading to intermittent or blocked flow and consequently non-uniformity of dosage. Measuring the ability of a powder to charge during a flow was a challenge. Nowadays, this measurement can be performed precisely with the instrument.
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A recent publication in the international journal « Particulate Science and Technology » shows how the allows characterizing the electrostatic properties of API/excipients blends. The publication demonstrate that the net charge of the blend is a complex function of the relative quantity of API and excipient in the mixture.
Moreover, both the quantity and the sign of the charge are found to depend on the material in contact with the powder during the flow. These results evidences the necessity to perform a measurement because the prediction of the triboelectric behavior of a blend is highly complex, in fact practically impossible.
Tribo-electrification of pharmaceutical powder blends
A. Rescaglio (ULiege), F. De Smet (UCB Pharma), L. Aerts (UCB Pharma) and G. Lumay (ULiege) https://www.tandfonline.com/doi/full/10.1080/02726351.2018.1533606