Flowing Properties Of Spray-Dried Powders Before And After Granulation - 2021

We study the flowing properties, the density and the packing dynamics of spray-dried powders produced with different nozzels and different airflow rates. At the exception of one powder, the obtained grains are small and have a low flowability due to cohesiveness. Therefore, an extra-streaming process is necessary before tableting. The spray-dried grains have been granulated with both High shear granulation (HSG) process and Fluid bed top spray granulation (FBG) process. The obtained granules have a lower cohesiveness than the spray-dried powder. We show how the association of three recently developed flow measurement techniques (improved angle of repose measurement with GranuHeap instrument, cohesiveness measurement with GranuDrum instrument and improved tapped density measurement with GranuPack instrument) can be used to draw conclusion about the process-ability in a tableting process. Finally, we show how these results are correlated with grain sizes/shape distributions.

Download Paper