Measuring the influence of talc on the properties of lactose powders - 2018

Granular materials, fine powders and nanostructured powders are widely used in many industrial applications.1 In particular, excipients are necessary in dry powder pharmaceutical formulations, such as dry powder inhalers (DPIs), tablets and capsules. Thus, insights regarding their behaviour and the effects of using of additives could have significant consequences for the optimisation of industrial processes, including avoiding technical issues like caking, clogging, noncompliance and non-conformity.To increase a powder’s processability, it is common to blend the excipient with an antistatic material in order to decrease the tribo-electric effect. This article will show how the addition of talc may affect lactose behaviour in terms of compaction dynamics, flowability, granulation and electrical charge. It will be also shown that the addition of antistatic agent addition is not always a viable solution.

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