Powder caking is important for industrial applications. Learn how the GranuPack can measure the caking and investigate it thanks to this application note.
In this study, we put the emphasis on the significance of the GranuFlow and how it elevates the standards of pharmaceutical powder testing.
B. Benque, L. Orefice, T. Forgber, M. Habeler, B. Schmid, J. Remmelgas, J. Khinast, Improvement of a pharmaceutical powder mixing process in a tote blender via DEM simulations, International Journal of Pharmaceutics, Volume 658, 2024, 124224, ISSN 0378-5173.
Lupo M, Neveu A, Gemine T, Francqui F, Lumay G, “Measuring permeability and flowability of powders at various packing fractions”. Particuology, 4 April 2024
Unravel the mystery of powder caking in industries like food and pharmaceuticals. Prolonged storage triggers aggregation, unveiling a tale of quality challenges and intrigue.
Orefice L, Remmelgas J, Neveu A, Francqui F, Khinast J.G, “A novel methodology for data analysis of dynamic angle of repose tests and powder flow classification”. Powder Technology, Volume 435, 15 February 2024, 119425
In this blog article, we explain what powder permeability is and its importance with the GranuPack Permeability.
Neveu A, Lupo M, Francqui F, “Powder Characterisation for Pharmaceuticals: Beyond Standards”. ONdrugDelivery, Issue 148 (May/June 2023), pp 16–19.
Pillitteri S, Neveu A, Zellnitz-Neugebauer S, “Powder Characterisation for DPI Performance in Capsule-Based Inhalers”. ONdrugDelivery, Issue 140 (Nov 2022), pp 77–81.
Learn more about powder caking with our new blog article.
For each experiment with the GranuPack, 500 taps were applied to the sample with a taps frequency of 1Hz and the measurement cell free-fall was 1 mm (∝ tap energy). The powder mass is recorded before each experiment...
The tap density test / tap test tool is a usefull compressibility tool commonly used in quality control and R&D for developing new formulations. This test can be used for calculating the Hausner ratio (Hr) or the Carr index value...
The excipient used during this application note is called Pharmatose 200M and was provided by DFE Pharma. This is a pharmaceutical α-lactose monohydrate and it is mechanically milled...
The main purpose of this application note is to provide information about the measurements reproducibility with the GranuFlow and to show some examples about what is it able to offer...
Electrostatic charges are created inside a powder during a flow. This apparition of electric charges is due to the triboelectric effect, which is a charge exchange at the contact between two solids...
When a powder is poured onto a surface, a heap is formed. It is well known that both the repose angle and the heap shape strongly depend on grain properties. In particular, a cohesive powder forms an irregular heap while a non-cohesive powder forms a regular conical heap.
The GranuFlow is a straightforward powder flowability measurement device composed of a silo with different apertures associated with a dedicated electronic balance to measure the flowrate...
One of the biggest advantages of the Dry Powder Inhaler (DPI) is that it allows a better preservation of the formulation due to the absence of water in the formulation...
Dry powder inhalers (DPI) offer many advantages to the respiratory administration. They show a targeted effect (they do not diffuse towards inappropriate sites in the body), they attain higher concentrations in the lungs resulting in a considerable reduced drug dose.